2018年5月3日，江蘇師范大學鄭元林、陸軍及吳冬梅共同通訊在Molecular Medicine（IF=5.7）在線發表題為“Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia”的研究論文，該研究表明，CREB1基因沉默導致VD加重，這是由于抑制PKA-CREB信號通路導致的，從而加劇了認知功能障礙。

但是，在2023年8月7日，該文章被撤回，主要原因是數據異常。

另外，國自然基金委對吳冬梅、鄭元林、陸軍等發表的論文共通報了35篇文章，截至2023年8月10日，已經被撤回33篇文章（部分文章為非通報文章）。

撤銷吳冬梅國家自然科學基金項目“TRPV4介導軟骨藻酸處理致小鼠認知缺陷的分子機制”（批準號81400902），追回已撥資金，永久取消吳冬梅國家自然科學基金項目申請資格（自2022年1月18日起），給予吳冬梅通報批評；

決定依照《國家自然科學基金條例》第三十五條第四項，并參照《國家自然科學基金委員會監督委員會對科學基金工作中不端行為的處理辦法（試行）》第十七條第三、四項，撤銷鄭元林國家自然科學基金項目“HDAC6激活HMGB1/RAGE信號軸介導Ⅱ型糖尿病小鼠認知缺陷的機制研究”（批準號81571055），追回已撥資金，取消鄭元林國家自然科學基金項目申請資格5年（2022年1月18日至2027年1月17日），給予鄭元林通報批評；

決定參照《國家自然科學基金委員會監督委員會對科學基金工作中不端行為的處理辦法（試行）》第十七條第三、四項，取消陸軍國家自然科學基金項目申請資格5年（2022年1月18日至2027年1月17日），給予陸軍通報批評。

吳冬梅、鄭元林、陸軍合作的撤稿文章列表（截至2023年8月10日共計33篇）：

[1]Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia,Molecular Medicine；

[2]The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells,Biomedicine & Pharmacotherapy；

[3]Long noncoding RNA nuclear enriched abundant transcript 1 impacts Cell proliferation, invasion, and migration of glioma through regulating miR-139-5p/ CDK6,Journal of Cellular Physiology；

[4]Repression of microRNA-382 inhibits glomerular mesangial cell proliferation and extracellular matrix accumulation via FoxO1 in mice with diabetic nephropathy,Cell Proliferation；

[5]Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-126-3p Inhibits Pancreatic Cancer Development by Targeting ADAM9,Molecular Therapy: Nucleic Acids；

[6]The role of HOTAIR-induced downregulation of microRNA-126 and interleukin-13 in the development of bronchial hyperresponsiveness in neonates,Journal of Cellular Physiology；

[7]MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor. Cancer Biomarkers；

[8]PTEN gene silencing contributes to airway remodeling and induces airway smooth muscle cell proliferation in mice with allergic asthma. Journal of Thoracic Disease；

[9]MicroRNA-182 downregulates Wnt/β-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9.Oncotarget；

[10]MicroRNA-433 inhibits oral squamous cell carcinoma cells by targeting FAK. Oncotarget；

[11]Mechanism of MicroRNA-708 Targeting BAMBI in Cell Proliferation, Migration, and Apoptosis in Mice With Melanoma via the Wnt and TGF-β Signaling Pathways. Technology in Cancer Research & Treatment；

[12]Inhibition of microRNA-200a Upregulates the Expression of Striatal Dopamine Receptor D2 to Repress Apoptosis of Striatum via the cAMP/PKA Signaling Pathway in Rats with Parkinson’s Disease. Cellular Physiology and Biochemistry；

[13]Long Non-Coding RNA LINC01260 Inhibits the Proliferation, Migration and Invasion of Spinal Cord Glioma Cells by Targeting CARD11 Via the NF-κB Signaling Pathway. Cellular Physiology and Biochemistry；

[14]Salidroside Protection Against Oxidative Stress Injury Through the Wnt/β-Catenin Signaling Pathway in Rats with Parkinson’s Disease. Cellular Physiology and Biochemistry；

[15]Micro-RNA-143 inhibits proliferation and promotes apoptosis of thymocytes by targeting CXCL13 in a myasthenia gravis mouse model. AJP Cell Physiology；

[16]MircoRNA-1275 promotes proliferation, invasion and migration of glioma cells via SERPINE1. Journal of Cellular and Molecular Medicine；

[17]S100A9 gene silencing inhibits the release of pro-inflammatory cytokines by blocking the IL-17 signalling pathway in mice with acute pancreatitis. Journal of Cellular and Molecular Medicine；

[18]Repression of microRNA-382 inhibits glomerular mesangial cell proliferation and extracellular matrix accumulation via FoxO1 in mice with diabetic nephropathy. Cell Proliferation；

[19]Protective effect of autophagy on endoplasmic reticulum stress induced apoptosis of alveolar epithelial cells in rat models of COPD. Bioscience Report；

[20]Down-regulation of XIAP enhances the radiosensitivity of esophageal cancer cells in vivo and in vitro. Bioscience Report；

[21]microRNA-136 inhibits proliferation and promotes apoptosis and radiosensitivity of cervical carcinoma through the NF-κB pathway by targeting E2F1. Life Sciences；

[22]Inhibition of the TGF-β1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model. Life Sciences；

[23]Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways. Brain Research Bulletin；

[24]Effect of microRNA-186 on oxidative stress injury of neuron by targeting interleukin 2 through the janus kinase-signal transducer and activator of transcription pathway in a rat model of Alzheimer’s disease. Journal of Cellular Biochemistry；

[25]MicroRNA-30d preserves pancreatic islet β-cell function through negative regulation of the JNK signaling pathway via SOCS3 in mice with streptozotocin-induced diabetes mellitus. Journal of Cellular Biochemistry；

[26]MicroRNA-421 suppresses the apoptosis and autophagy of hippocampal neurons in epilepsy mice model by inhibition of the TLR/MYD88 pathway. Journal of Cellular Biochemistry；

[27]Protective effects of microRNA-431 against cerebral ischemia-reperfusion injury in rats by targeting the Rho/Rho-kinase signaling pathway. Journal of Cellular Biochemistry；

[28]LncRNA LINC00880 promotes cell proliferation, migration, and invasion while inhibiting apoptosis by targeting CACNG5 through the MAPK signaling pathway in spinal cord ependymoma. Journal of Cellular Biochemistry；

[29]Down-regulated long non-coding RNA ANRIL restores the learning and memory abilities and rescues hippocampal pyramidal neurons from apoptosis in streptozotocin-induced diabetic rats via the NF-κB signaling. Journal of Cellular Biochemistry；

[30]Effects of S100A12 gene silencing on serum levels of anti-inflammatory/pro-inflammatory cytokines in septic rats through the ERK signaling pathway. Journal of Cellular Biochemistry；

[31]MicroRNA-381-induced down regulation of CXCR4 promotes the proliferation of renal tubular epithelial cells in rat models of renal ischemia reperfusion injury. Journal of Cellular Biochemistry；

[32]Effects of long noncoding RNA SPRY4-IT1-mediated EZH2 on the invasion and migration of lung adenocarcinoma. Journal of Cellular Biochemistry；

[33]MCL1 gene silencing promotes senescence and apoptosis of glioma cells via inhibition of the PI3K/Akt signaling pathway. IUBMB Life.

版權聲明

本文來源：iMedicines，版權屬于原作者，僅用于學術分享